Abstract: The development of smart grid informatization and intellectualization requires real-time processing and fast analyzing of multi-source and multi-dimensional, massive and complex information data of power grid to achieve intelligent decision-making and timely dispatching of smart grid. In this paper, the information management of smart grid orienting to real-time monitoring information is studied based on multi-agent technology. Firstly, the significance and technical support for realizing informatization and intellectualization of smart grid are discussed. Then, the framework of information management system of smart grid is presented based on multi-agent technology, and relative design methods and functions of Agents in device level, subsystem level and system level are mainly studied. In the end, the algorithms of implementing the information management system are given based on multi-agent technology, and system functions are testified and analyzed by using test examples. The research works provide technical support for the informatization and intellectualization of smart grid.