Abstract: As to distribution adjustment of power plant, the reliability of power supply, the stability of angle and voltage, and loss of active power can be calculated in parallel by comprehensively using of power flow analysis technique, the optimized approach, reliability theory and stability analysis method. Taking the regional planning for power grid of East China in 2015 with six sets of power plant adjustment schemes as example, the effect of distribution adjustment of power plant on the safety and energy\|saving of power grid is analyzed, then suggested scheme of power plant adjustment is given. The results show that power plants that are properly configured in load center can help to improve reliability and stability of power grid and reduce losses, which achieve better whole energy\|savings.