Abstract: With the extensive use of advanced metering infrastructure(AMI)in the smart grid, the power grid produces massive sample information data, and the detailed information of power system operation can be obtained by clustering analysis. In this paper, the classical clustering and hybrid clustering methods commonly used in power system are generalized, and the evaluation index of clustering results is summarized. Besides, the application of cluster analysis in power system load forecasting, power quality disturbance analysis, islanding detection, partial discharge and demand response are analyzed. Finally, the research and development prospect of cluster analysis technology in power system is forecasted.