Abstract: Multi-energy flow calculation of integrated energy system is the basis and premise of energy management and regulation. To solve the problems of high complexity and low convergence efficiency during the energy flow calculation process with traditional unified calculation method, a multi-energy flow calculation method for integrated energy system considering different operation modes of energy hub was proposed. Based on the energy hub modeling, the independent calculation model of the hybrid energy flow was established and the typical operation modes were analyzed. Relaying on the clamp constraints of EH input and output, the independent calculation results of each energy subsystem can be corrected iteratively, so as to realize the standardization solution flow under different operation modes. Testing case results show that operation modes of energy hub make great influence on the multi-energy flow distribution, besides, the calculation method, which takes different operation modes of energy hub into account, can achieve good convergence efficiency and is of certain rationality.