Abstract: To improve the energy utilization, regional integrated energy system (abbr. RIES) implement the complementation of the advantages of multi energy sources by the coupling of energy hub. Considering the great significance of variable condition operation of energy conversion equipment for improving the economy of optimal allocation of integrated energy system, firstly, on the basis of analyzing the variable conditions characteristics of energy coupling equipments a dynamic model of the equipment under variable conditions was proposed, and the conversion matrix of the energy hub was improved. Secondly, based on typical daily load curves, an optimal allocation of water resources model for RIES, in which the minimum annual investment of the system and the optimum of daily operation economy of the system were taken as the objectives, was established. Finally, combining with computing example, the results of capacity configuration and equipment output in different scenarios were analyzed. Analysis results show that in the optimal configuration of RIES the consideration on the variable conditions characteristics of energy hub can effectively reduce the cost of putting integrated energy system into operation, so it is beneficial to implement the reasonable configuration of integrated energy system.