Weather factors have a significant impact on the economic dispatch of V2H microgrid. Only to quantify the impact from the supply or demand side cannot reflect the actual linkage between the source and load. Starting from the analysis of typical V2H microgrid structure, establishes the output model of photovoltaic and energy storage devices affected by weather on the supply-side, and the load model of electric vehicles and households affected by weather on the demand side. Therefore, this paper builds a V2H microgrid economic dispatching model with minimal local user energy expenditure cost as the optimized objective. PSO algorithm is used to solve the optimized strategies under four typical weather conditions. The simulation results show that it is necessary to configure a reasonable energy storage unit to overcome the remarkable weather’s influence on the economic benefits of V2H microgrid. The size, charging and discharging time, and other performance parameters have a direct impact on the optimal dispatching scheme. The economic dispatching model considering both supply and demand sides can reflect the actual system linkage better than the traditional single-side dispatch model, which verifies the rationality and effectiveness of the proposed model.