Abstract: To improve the economic operation level at both supply and demand sides of microgrid, the influences of price elastic coefficient uncertainty on the cost at the both sides was analyzed. Firstly, at the demand side of microgrid, a demand-response cost-effectiveness model, in which the uncertainty of price elastic coefficient was taken into account, was established. Secondly, at the supply side of microgrid, taking economic operation cost and environment cost as optimal objectives and combining with practical operational constraints in microgrid, an economic operation optimization model of microgrid, in which the uncertain price demand response was taken into account, was established, and then a new hybrid difference particle swarm optimization was proposed as the solving method for the established optimization model, in which the benchmark functions was utilized to conduct the contrastive test to verify the effectiveness and reliability of the improved algorithm. Simulation results show that the demand response cost of microgrid increases while the price elastic uncertain factor is taken into account, besides, the operation benefit at the supply side of microgrid decreases to some extent while the uncertain factors are added.